ناقشت بنجاح طالبة الماجستير ساره كامل جرادات من قسم الصيدلة السريرية يوم الأثنين الموافق 15/5/2017م أطروحة الماجستير بعنوان:
CORRELATION OF GLYCEMIC STATUSWITH
ANTHROPOMETRIC MEASUREMENTS AND TUMOR CHARACTERISTICS IN BREAST CANCER PATIENTS
وقد ضمت لجنة المناقشة الدكتورة نهاد أيوب رئيساً وعضوية كل من الدكتور أحمد الحسبان والدكتورة ليندا طحاينه والدكتور محمد خطاطبة والدكتورة أمل عكور كممتحن خارجي. باسم صفحة أصدقاء كلية الصيدلة_ في جامعة العلوم والتكنولوجيا الأردنية نبارك للطالبة ساره جرادات إتمامها درجة الماجستير في الصيدلة السريرية بنجاح وتفوق متمنين لها مزيدا من التقدم.
للإطلاع على ملخص الدراسة
Breast cancer is the most common
malignancy and a leading cause of cancer mortality among women worldwide. Women diagnosed with
breast cancer often have comorbid conditions in addition to their primary
cancer diagnosis. Treatment decisions regarding breast cancer are taken with
isolation from the concurrent presentation of comorbidities and metabolic
abnormalities of patients which may have an impact on treatment outcomes and
survival of patients. Apart from common molecular target for breast cancer
treatment, identification of modifiable risk factors for breast cancer is an
expanding area of research. Modifiable risk factors may alter clinical,
pathological, and prognostic characteristics of breast cancer patients. The goal of this
study was to evaluate the
association between glycemic status, determined by HbA1c levels, and
anthropometric measurements and disease characteristics among breast cancer
patients. This cross-sectional study included adult female (n=223) with
histologically confirmed breast cancer diagnosis who attended Chemotherapy
Clinic at Oncology Unit at Royal Medical Services (RMS), Amman, Jordan.
Demographic and life style data were collected from patients at interviewed by
filling a special data collection form.Anthropometric measures were recorded at
presentation including weight, height, waist circumference, and hip
circumference. Clinico-pathologic characteristics were retrieved from pathology
reports for patients issued by Pathology Department at RMS. HbA1c levels were
measured in blood samples for patients who were enrolled in study. Of the 223
patients enrolled, 75 (33.6%)were classified to have normal levels of HbA1c
levels, 99 (44.4%) were pre-diabetics, and 49 (22%) were diabetic. Mean body mass index (BMI) among breast cancer patients was
29.90±5.70 kg/m2.HbA1c
levels were positively and significantly correlated with age (r=0.267, P<0.001), waist circumference (r=0.180,P=0.008) and waist-hip ratio (r=0.278,
P<0.001) among breast
cancer patients. Mean HbA1c levels were statistically higher among
postmenopausal patients compared to premenopausal cases (t=–3.542, P=0.003).
HbA1c status was not significantly associated with breast cancer
characteristics in terms of tumor size (P= 0.409), lymph node status (P=0.292), tumor stage (P=0.100), tumor
grade (P=0.548),
and histologic subtypes (P= 0.288). In addition, HbA1c status was not associated with
receptor status and molecular subtypes among breast cancer patients. Collectively,
glycemic status was significantly associated with measures of central obesity
as indicated by waist circumference and waist-hip ratio. Most breast cancer
patients have impaired blood glucose levels in which a considerable proportion
of patients classified as pre-diabetics. Glycemic status lacked association
with clinico-pathologic characteristics among breast cancer patients. Future
investigations are needed to better evaluate the impact of glycemic status on
prognosis of breast cancer patients and its impact on disease outcomes
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