ناقشت بنجاح طالبة الماجستير رجاء جهاد بدارنة من قسم الكيمياء الطبية والعقاقير يوم الخميس الموافق 3/12/2015م أطروحة الماجستير بعنوان:
Design and Synthesis of Novel Thiazole Based Scaffold
Derivatives Targeting Glyoxalase-I Enzyme as Anti-Cancer Candidates
وقد ضمت لجنة المناقشة الدكتورة بثينة العودات رئيساً وعضوية كل من الدكتور قصي البلص والدكتور نزارالشرع والدكتور غسان أبو شيخه كممتحن خارجي.
باسم صفحة أصدقاء كلية الصيدلة_ في جامعة العلوم والتكنولوجيا الأردنية نبارك للطالبة رجاء بدارنة إتمامها درجة الماجستيرفي الكيمياء الطبية والعقاقير بنجاح وتفوق متمنين لها مزيدا من التقدم.
* للاطلاع على ملخص الدراسة:
It has been established
that the glutathione-dependent glyoxalase enzyme is a plausible target in
cancer treatment. Glyoxalase enzyme system consists of two enzymes, glyoxalase
I (GlxI) and glyoxalase II (GlxII) and a catalytic amount of glutathione (GSH).
The enzyme system performs a detoxification function in human cells in which it
catalyses the conversion of the cytotoxic methylglyoxal, the simplest of
α-ketoaldehydes, to non-toxic D-lactic acids. Methylglyoxal cytotoxicity is due
to its ability to form adducts with proteins and nucleic acids. Among the two
enzymes of the glyoxalase detoxification pathway, GlxI has been targeted for
the development of potential anti-cancer agents. Inhibition of GlxI in
cancerous cells would induce elevated concentration of the cytotoxic
methylglyoxal leading to apoptosis. GlxI is a dimeric zinc metallo-enzyme in
which the zinc atom is a required chemical feature for binding with the
inhibitor in the active site. In the present study, a series of potential GlxI
inhibitors will be designed, synthesized, and tested for their biological activity
against both the enzyme and cancer cell lines. These inhibitors are novel
compounds possessing a zinc binding group and a thiazole based scaffold
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