ناقشت بنجاح طالبة الماجستير الآء طارق عتمة من قسم الصيدلة السريرية يوم الأحد الموافق 20/03/2016م بعنوان:
" تقييم تأثير الليفوسيمندان على التعلم والذاكرة في الجرذان "
The Effect of Levosimendan on Learning and Memory in Rat Animal Model
وقد ضمت لجنة المناقشة الدكتورة عبير ربابعة رئيساً وعضوية كل من الأستاذ الدكتور كارم الزعبي والدكتور نزار مهيدات والأستاذ الدكتور عبلة بصول كممتحن خارجي.
باسم صفحة أصدقاء كلية الصيدلة_ في جامعة العلوم والتكنولوجيا الأردنية نبارك للطالبة الآء طارق عتمة إتمامها درجة الماجستير في الصيدلة السريرية بنجاح وتفوق متمنين لها مزيدا من التقدم.
* للإطلاع على ملخص الدراسة:
Background: Learning and memory impairment has been associated with elevated and accumulated level of reactive oxygen species. It has been validated through the literature that antioxidants enhance learning and memory. Additionally, it has been shown that inhibition of phosphodiesterase enzyme activity will improve memory deficit. Levosimendan is a cardiac inotropic and vasodilator agent that had been introduced to have a pleotropic effect such as antioxidant, anti-inflammatory and smooth muscle vasodilatory effects. Furthermore, Levosimendan inhibits phosphodiesterase-III (PDE-III) enzyme
In this study, the effect of Levosimendan on learning and memory was investigated
Methods: The adult male Wistar rats were separated into two groups; control and Levosimendan groups. Levosimendan (12µg/kg) was administrated intraperitoneally once weekly for 8 weeks. Radial arm water maze (RAWM) was used to assess spatial learning and memory. Additionally, brain derived neurotrophic factor (BDNF) level, thiobarbituric acid reactive substance (TBARS) level, and levels of antioxidant defense biomarkers such as reduced glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG ratio, glutathione peroxidase (GPx), catalase, and superoxide dismutase (SOD) were assessed in the hippocampus
Results: Levosimendan significantly enhances short-term memory and long-term (5 hours) memory. Additionally, we showed that Levosimendan treated group significantly increases GPx and GSH levels (p<0.05), and significantly decreases TBARS level (p<0.05). There were no significant changes observed between the two study groups in the level of other antioxidants and stress biomarkers such
Methods: The adult male Wistar rats were separated into two groups; control and Levosimendan groups. Levosimendan (12µg/kg) was administrated intraperitoneally once weekly for 8 weeks. Radial arm water maze (RAWM) was used to assess spatial learning and memory. Additionally, brain derived neurotrophic factor (BDNF) level, thiobarbituric acid reactive substance (TBARS) level, and levels of antioxidant defense biomarkers such as reduced glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG ratio, glutathione peroxidase (GPx), catalase, and superoxide dismutase (SOD) were assessed in the hippocampus
Results: Levosimendan significantly enhances short-term memory and long-term (5 hours) memory. Additionally, we showed that Levosimendan treated group significantly increases GPx and GSH levels (p<0.05), and significantly decreases TBARS level (p<0.05). There were no significant changes observed between the two study groups in the level of other antioxidants and stress biomarkers such
as: SOD, GSSG, GSH/GSSG ratio, catalase and BDNF (p>0.05)
Conclusion, Levosimendan as antioxidant agent enhances short term memory and long term (5 hours) memory through potentiating antioxidant defense mechanism in hippocampus
Conclusion, Levosimendan as antioxidant agent enhances short term memory and long term (5 hours) memory through potentiating antioxidant defense mechanism in hippocampus
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