أطروحة الماجستير للطالبة زينب يحيى الصبح من قسم الصيدلة السريرية

ناقشت بنجاح طالبة الماجستير زينب يحيى الصبح من قسم الصيدلة السريرية اليوم الخميس الموافق 5/5/2016م أطروحة الماجستير بعنوان:

" تقييم فعالية مركب الإيتازوليت في التخفيف من أعراض القلق والاكتئاب وضعف الذاكرة الناتج عن اضطراب ما بعد الصدمة "

Evaluating the Protective Effect of Etazolate on Anxiety & Depression- Like Behavior & Cognitive Impairment Induced by Post Traumatic Stress Disorder

وقد ضمت لجنة المناقشة الأستاذ الدكتور كارم الزعبي رئيساً وعضوية كل من الدكتور عمر خابور والدكتور نزار مهيدات والأستاذ الدكتور عبلة بصول كممتحن خارجي.

باسم صفحة أصدقاء كلية الصيدلة_ في جامعة العلوم والتكنولوجيا الأردنية نبارك للطالبة زينب الصبح إتمامها درجة الماجستير في الصيدلة السريرية بنجاح وتفوق متمنين لها مزيدا من التقدم.

* للإطلاع على ملخص الدراسة:

Background: Post-traumatic stress disorder (PTSD) is neuropsychiatric disorder that develops after individual experiences severe, life-threatening traumatic stress. PTSD has a lifetime prevalence of 8-10% and often co-morbid with various neuropsychiatric diseases.

Etazolate is selective phosphodiesterase IV inhibitor that is highly specific for cAMP and proven to be of particular importance in neuro-psychopharmacology. Etazolate shows anxiolytic and antidepressant effect and could also be a lead candidate for Alzheimer’s disease.

Aim: To evaluate the role of etazolate in preventing anxiety, depression, and cognitive impairment associated with PTSD.

Method: PTSD was induced by single prolonged stress (SPS) model. Elevated plus maze test, open field, and tail suspension were conducted as behavioral tests of anxiety- and depression-like symptoms, while radial arms water maze was used to evaluate cognitive function. Etazolate was administered orally at a dose of 1mg/kg/day and its protective effect was compared to other control group. At the end, hippocampus was dissected and antioxidant markers and BDNF protein level were assessed.

Findings: Results revealed that PTSD is associated with symptoms of anxiety and depression and impairment in both short and long term memory. Etazolate administration significantly prevents these PTSD related symptoms. Moreover, etazolate significantly normalize oxidative stress related parameters (GSH, GSSG, GPx, TBARS) and BDNF levels.  

Conclusion: Anxiety, depression, and memory deficits induced by PTSD can be significantly prevented with etazolate probably through enhancing antioxidants capacity and BDNF level in PTSD animals.