ناقشت بنجاح طالبة الماجستير علا علي بدير من قسم الصيدلة السريرية يوم الأربعاء
الموافق 30/12/2015م بعنوان:
وقد
ضمت لجنة المناقشة الدكتورة ميرا عبابنة رئيساً وعضوية كل من الدكتور نزار مهيدات
والدكتورة باسمة المومني والدكتور محمد خطاطبة والدكتور فراس الحجي كممتحن خارجي.
باسم
صفحة أصدقاء كلية الصيدلة_ في جامعة العلوم والتكنولوجيا الأردنية نبارك للطالبة
علا بدير إتمامها درجة الماجستير في الصيدلة السريرية بنجاح وتفوق متمنين لها
مزيدا من التقدم.
*
للإطلاع على ملخص الدراسة:
Background and Aims: Yeasts, mostly Candida, are important
causes of bloodstream infections (BSI), accounting for significant mortality
and morbidity between hospitalized patients. The epidemiology and species
distribution vary among different regions. The main goal of this study was to
report the epidemiology of Candida BSI at King Abdullah University Hospital
)KAUH( over a 10-year period. Other aims were to identify risk factors involved
in infections caused by non- Candida albicans species and to report risk
factors associated with 30-day mortality.
Methods: This was a retrospective
observational study. The medical and electronic records of patients who had
candidemia at KAUH hospital from 2005 to 2014 were reviewed for demographic and
clinical information, including the infecting Candida species, resistance to
antifungal, and the risk factors associated with mortality. Univariate and
multivariable analyses were performed to determine these factors.
Results: A total of 158 cases of Candida BSI were
identified, with an incidence rate of 0.48 episodes/1,000 admissions (0.32 in
2008 and 0.72 in 2009). The proportion of candidemia caused by C. albicans
(44.30%) was higher than that of candidemia caused by non. albicans species
(42.41%). The main species of non-albicans were C. parapsilosis (14.56%), C.
tropicalis (10.76%), and C. glabrata (6.33%). Comparison of C. albicans and
non-Candida albicans candidemia by multivariate logistic regression showed that
antibiotic before hospitalization (OR 2.454; P = 0.033) was the only factor
associated with non-Candida albicans candidemia. The overall crude 30-day
mortality was 38.7%. Central venous catheterization (OR 0.255; P = 0.026),
mechanical ventilation (OR 0.162; P = 0.003), sever sepsis and Septic shock (OR
=0.073; P = 0.008), admission to intensive care unit (ICU) (OR 0.78; P =
0.001), C. albicans (OR0.235; P = 0.018), length of stay (OR1.057; P =0.001),
number of comorbidities (OR 0.580; P = 0.008) were independent risk factors for
30-day mortality.
Conclusion: This
study is the first epidemiological study of Candida BSIs in a Jordanian
tertiary care hospital. The awareness of the local epidemiological trends in
Candida species isolated from blood cultures is important to guide therapeutic
management. We reported multiple
independent risk factors for 30-day mortality in candidemia patients. Therefore, previous knowledge about such
factors can have a huge impact on the management of candidemia and clinical
outcomes.
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